Relationship of Podoplanin and Glutathione S-transferases T1 Expression with Laryngeal Cancer

Document Type : Original Article

Authors
Deniz Kanliada 1
Ender Coskunpinar 2
Kadir Serkan Orhan 1
Yasemin Musteri Oltulu 2
Mehmet Celik 1
Ayse Eren 2
Ilhan Yaylim 2
Kemal Deger 2
1 Department of ORL and Head&Neck Surgery, Istanbul Faculty of Medicine, Istanbul, Turkey
2 Department of Molecular Medicine, Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey
Abstract
The aim of this study is to determine whether there is a role of podoplanin and glutathione S-transferases T1
(GST-T1) expression in laryngeal squamous cell carcinoma.
The study was completed with 33 patients and gene expression analysis was performed by qRT–PCR. The
podoplanin and GST-T1 expression patterns were analyzed to determine their correlation with clinicopathologic
parameters of laryngeal cancer.
Of all patients, 20 had supraglottic, and the remaining 13 had glottic laryngeal cancer. Increased expression of
podoplanin was found in 14 tumor tissues, but GST-T1 expression was not detected.
Podoplanin expression did not show any prediction for regional metastasis, thyroid cartilage invasion, lymphatic
vessel invasion or tumor differentiation for laryngeal cancer, also there were no significant differences in
podoplanin expression between glottic and supraglottic regions, but extracapsullar extension is almost
statistically significant (p=0,05).
Keywords
Podoplanin
GST-T1
laryngeal carcinoma
biomarker
squamous cell carcinoma