Polymorphism of Genes and Implantation Failure

Document Type : Review Article

Authors
1 Department Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2 Medical Genetics Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract
Implantation failure is the most frequent cause of pregnancy loss in couples who try to conceive, either in a
natural way or using assisted reproductive techniques (ART). Identify the precise mechanisms of implantation
failure can lead to identify couples at risk and also providing appropriate therapeutic options to affected couples.
Despite the high prevalence of this disorder, a few causing factors are demonstrated so far. Recent studies
indicate that genetic factors play an important role in the occurrence of recurrent implantation failure. Although
some of these factors, such as numerical chromosomal aneuploidy are known to be causative factors, there are
some other factors that solely increase susceptibility to this event. In the present review we try to list the genetic
polymorphisms that are known as susceptibility factors in implantation failure.
Keywords