Is Radiosensitivity Associated to Different Types of Blood Groups? (A cytogenetic study)

Document Type : Original Article

Authors
Farideh Elahimanesh 1
Ali Shabestani Monfared 1
Meysam Khosravifarsani 1 , 2
Haleh Akhavan Niaki 1
Zeinab Abedian 1
Karimollah Hajian-Tilaki 1
Sajad Borzouisileh 1
Nayer Seyfizadeh 1 , 3
Mehrangiz Amiri 1
1 Cellular & Molecular Biology Research Center (CMBRC), Babol University of Medical Sciences, Babol, Iran
2 Department of Radiology, Faculty of Medicine, Kurdestan University of Medical Sciences, Kurdestan, Iran.
3 Department of Clinical Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Abstract
Many biological factors affect radiosensitivity. In this study, radiosensitivity among the different blood groups
was investigated. Peripheral blood sample of 95 healthy people were divided into two parts. One part was
irradiated with 2 Gy Co-60 gamma rays and the second one was considered as control. Then all the samples were
studied by cytokinesis-blocked micronucleus assay (CBMN assay). Our study showed that the radiosensitivity
index of A+ and O+ groups was significantly higher and lower than other blood groups, respectively. It seems
that blood type can be used as a radiosensitivity index for determining the given dose to radiotherapy, although
extensive studies are necessary.
Keywords
Radiosensitivity
blood group
CBMN assay