C - Reactive Protein Levels in Patients with Periodontal Disease and Normal Subjects

Document Type : Original Article

Authors
Mahdieh Shojaee 1
Majid Fereydooni Golpasha 2
Ghorban Maliji 3 , 4
Ali Bijani 5
Seyed Mohsen Aghajanpour Mir 3
Seyede Narges Mousavi Kani 3
1 School of Dentistry, Babol Universityof Medical Sciences, Babol, Iran
2 Dental Material Reaserch Center, Assistant Professor of the Periodentology Department, School of Dentistry, Babol University of Medical Sciences, Iran
3 Cellular and Molecular Biology Research Center (CMBRC), Babol Universityof Medical Sciences, Babol, Iran
4 Department of Immunology, School of Medicine, Babol University of Medical Sciences, Iran
5 Non-Communicable Pediatric Disease Research Center, Babol University of Medical Sciences, Babol, Iran
Abstract
Although periodontitis is a chronic inflammatory disease but some factors of acute inflammation phase are
involved in this disease among which is the C-Reactive protein (CRP). To minimize its effects, antiinflammatory drugs or non-pharmacological approaches such as oral hygiene is recommended. CRP can also be
used for the prediction and early detection of periodontal disease. The aim of the present study was the
comparison of the amount of salivary C-Reactive protein (CRP) in healthy subjects and patients with periodontal
disease. This case-control study was done on 90 patients referred to the Department of Periodontology of Babol
Dentistry School. These subjects were divided into three groups of healthy (n = 30), gingivitis (n = 30), and
chronic periodontitis (n = 30), based on Gingival Index (GI) and Clinical Attachment Loss (CAL) indices. 2ml
saliva samples were collected from these people and clinical indicators including GI, CAL, Periodontal Pocket
Depth (PPD), and Bleeding Index (BI) were assessed. ELISA method was used to evaluate the salivary CRP
levels. Collected data were analyzed using SPSS statistical software by non-Parametric Kruskal-Wallis and
Mann-Whitney test and Spearman correlation coefficient and P<0.05 was considered significant. The mean
salivary CRP levels were 5332.62±5051.63pg/ml in periodontitis patients, 3545.41±3061.38pg/ml in gingivitis
group and 3108.51±3574.47pg/ml in healthy subjects. The statistic analysis showed a significant difference in
salivary CRP concentrations between the periodontitis patients and healthy subjects (P=0.045). The results
indicate that there is a significant association between periodontitis and salivary CRP concentrations.
Keywords
CRP
periodontitis
gingivitis
saliva