Early Renal Histological Changes in Alloxan-Induced Diabetic Rats

Diabetes mellitus is a progressive disease. Most investigators have focused on glomerular changes in diabetic
kidney and non-glomerular alterations have been less attended. The present study has been conducted to find
early non-glomerular histological changes in diabetic renal tissue. Twenty male Wistar rats weighting 200-250 g
were used for the diabetic group. Diabetes mellitus was induced by single injection of Alloxan. After 8 weeks,
paraffin embedded blocks of kidneys were prepared for evaluating the histological changes due to diabetes.
Histological study showed the deposit of eosinophilic materials in the intermediate substantial of medulla and
thickening of renal arterial wall in the kidney of 70% of diabetic rats. The average weight of kidneys increased
when compared to non diabetic animals. Furthermore, the amount of blood flow in arteries of all diabetic
kidneys has been enhanced. The present study demonstrates some early renal histological changes in diabetes
mellitus which were earlier compared to those reported previously. Diabetic nephropathy is a progressive disease
and renal care design can help better prognosis achievement.