1
Department of Microbiology, Qom branch, Islamic Azad University, Qom 37185-364, Iran
2
National Institute of Genetic Engineering and Biotechnology, Department of Molecular Genetics, Tehran, Iran
3
Department of Clinical Biochemistry, Faculty of Medicine, Golestan University of Medical Sciences, Golestan, Iran
4
Department of Otolaryngology, Kashan University of Medical Sciences, Kashan, Iran
5
Department of Biology, Faculty of Science, University of Zabol, Zabol, Iran
Abstract
The prevalence of Hepatitis C virus (HCV) is approximately 3% around the world. This virus causes chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. The effectiveness of interferon-α and ribavirin therapy is about 50% and is associated with significant toxicity and cost. Hence, generating new vaccines or drugs is an obligation. However, there is no vaccine available for clinical use. DNA vaccines have some advantages such as producing feasibility and generating intensive cellular and humoral immune responses. Activation and improvement of natural immune defense mechanisms is a necessity for the development of an effective HCV vaccine. This article discusses the current status of therapies for hepatitis C, the promising new therapies and the experimental strategies to develop an HCV vaccine.
Naderi, M., Gholipour, N., Zolfaghari, M. R., Moradi Binabaj, M., Yegane Moghadam, A. & Motalleb, G. (2014). Hepatitis C Virus and Vaccine Development. International Journal of Complementary and Integrative Health, 3(4), 207-215.
MLA
Naderi, M., Gholipour, N., Zolfaghari, M. R., Moradi Binabaj, M., Yegane Moghadam, A., & Motalleb, G. "Hepatitis C Virus and Vaccine Development", International Journal of Complementary and Integrative Health, 3, 4, 2014, 207-215.
HARVARD
Naderi M., Gholipour N., Zolfaghari M. R., Moradi Binabaj M., Yegane Moghadam A., Motalleb G. (2014). 'Hepatitis C Virus and Vaccine Development', International Journal of Complementary and Integrative Health, 3(4), pp. 207-215.
CHICAGO
M. Naderi, N. Gholipour, M. R. Zolfaghari, M. Moradi Binabaj, A. Yegane Moghadam & G. Motalleb, "Hepatitis C Virus and Vaccine Development," International Journal of Complementary and Integrative Health, 3 4 (2014): 207-215,
VANCOUVER
Naderi M., Gholipour N., Zolfaghari M. R., Moradi Binabaj M., Yegane Moghadam A., Motalleb G. Hepatitis C Virus and Vaccine Development. Int J Complement Integr Health. 2014;3(4):207-215.