Rab11 in Disease Progression

Abstract: Membrane/protein trafficking in the secretory/biosynthetic and endocytic pathways is mediated by
vesicles. Vesicle trafficking in eukaryotes is regulated by a class of small monomeric GTPases: the Rab protein
family. Rab proteins represent the largest branch of the Ras superfamily GTPases, and have been concerned in a
variety of intracellular vesicle trafficking and different intracellular signalling pathways. Rab11 (a subfamily of
the Ypt/Rab gene family), an evolutionarily conserved ubiquitously expressed subfamily of Rab GTPases, has
been implicated in regulating vesicular trafficking through the recycling of endosomes. Rabs have been grouped
into different subfamilies based on the distinct unambiguous sequence motifs. Three members: Rab11a, Rab11b
and Rab25 make up the Rab11 GTPase subfamily. In this review article, we describe an overview over Rab11
subfamily with a brief structural aspect and its roles in implicating different disease progression.