APOBEC3 Deletion is Associated with Breast Cancer Risk in a Sample of Southeast Iranian Population

Document Type : Original Article

Authors
Maryam Rezaei 1 , 2
Mohammad Hashemi 1 , 2
Seyed Mehdi Hashemi 3
Mohammad Ali Mashhadi 3
Mohsen Taheri 2 , 4
1 Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
2 Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
3 Department of Internal Medicine, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
4 Genetics of Non-Communicable Diseases Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
Abstract
Breast Cancer (BC) is considered as one of the most important causes of death worldwide. Previous studies
showed that apolipoprotein B mRNA- editing catalytic polypeptide-like 3 (APOBEC3) gene deletion
significantly increased the risk of BC risk in Chinese and European women. The present study aimed to assess
the possible impact of APOBEC3 deletion and the risk of BC in a sample of Iranian population. The APOBEC3
insertion/deletion (I/D) was analyzed in a case- control study including 262 BC patients and 217 healthy women.
Polymerase chain reaction (PCR) was used to genotype the variant in APOBEC3 gene. The findings of this study
showed that I/D as well as I/D+D/D genotype increased the risk of BC (OR= 1.57, 95% CI= 1.07- 2.31, p= 0.025
and OR= 1.50, 95% CI= 1.03- 2.19, p= 0.037, respectively) in comparison with I/I genotype. In conclusion, our
findings suggest that APOBEC3 deletion polymorphism increased the risk of BC in an Iranian population in the
southeast of Iran.
Keywords
APOBEC3
breast Cancer
polymorphism
deletion