A Comparison Between the Effect of Cuminum Cyminum and Vitamin E on the Level of Leptin, Paraoxonase 1, HbA1c and Oxidized LDL in Diabetic Patients

Document Type : Original Article

Authors
Ghatreh Samani Keihan 1
Mohammad Hossein Gharib 1
Ali Momeni 2
Zohreh Hemati 3
Roya Sedighin 3
1 Clinical Biochemistry Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
2 Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
3 Shahrekord University of Medical Sciences, Shahrekord, Iran
10.22088/acadpub.BUMS.5.4.229
Abstract
Diabetes is one of the most common metabolic diseases in the world. Vitamin E reduces protein glycation and
improves insulin sensitivity, while cumin is effective in remission of diabetes. Therefore this study was designed
to evaluate the effects of vitamin E and cumin essential oil, on the blood level of leptin,glycosylated hemoglobin
(HbA1C) and also on lipid profile in diabetic patients.In this double blind clinical trial, 95 diabetic patients were
selected and randomly dividedinto three groups.The first group received cumin essential oil in capsule form. The
second group received Vitamin E, and the third group was used ascontrol receiving oral gelatin capsules as
placebo for three months period.Blood glucose, lipid profile, apolipoprotein A1 (ApoA1), apolipoprotein B
(ApoB), leptin, HbA1c, oxidized LDL (oxLDL), and paraoxonase1 activity were measured. The results showed
reduction in oxLDL and significant increase in paraoxonase 1 in Vitamin E group by the end of the third month
period (P<0.05). Cumin group showed decrease in blood glucose, HbA1C, triglyceride, leptin and ox-LDL.
ApoA1 and paraoxonase1 were also increased by cumin treatment (P<0.05).Diabetic complications may have
been reduced by intake of Vitamin E and cumin essential oil. Cumin in comparison with vitamin E has broader
impact and it is more beneficial in terms of ability to reduce the diabetic index.
Keywords
Diabetes
vitamin E
cumin
leptin
paraoxonase1
oxidized LDL