LINC01366 and LINC01433 in Glioblastoma Multiforme: A Potential Roleat the Intersection of Inflammation and Angiogenesis

Glioblastoma multiforme (GBM) is an aggressive cancer with a poor prognosis. Inflammation
and angiogenesis are important processes in GBM that are interrelated. In this study,
bioinformatic investigations were performed to detect common and key genes in the
inflammatory and angiogenesis pathways of GBM. Additionally, relevant long non-coding
RNAs (lncRNAs) were recognized as important gene regulators. Consequently, real-time PCR
and correlation analyses were used to investigate changes in gene and lncRNA expression levels
and explain their relationship. RELA emerged as a common key gene in these biological
processes. LINC01366 and LINC01433 were identified as putative RELA regulators in different
metabolic pathways using computational assays. According to our findings, the expression
levels of RELA, LINC01366 and LINC01433 were found to be significantly upregulated in
GBM samples. Correlational studies revealed a significant positive relationship of gene
expressions between LINC01366 and LINC01433, indicating that they may have a coordinated
effect on GBM biology. Nevertheless, there was no significant correlation between these
lncRNAs and RELA. The current study highlights the high expression of LINC01366 and
LINC01433 in GBM and emphasizes the importance of studying lncRNAs as putative regulators
in the pathophysiology of GBM. Further research is needed to clarify their specific functions, in
particular the associated inflammatory and angiogenesis pathways.