Colorectal Cancer; Novel Approaches in Chimeric Antigen Receptors(CAR) -T cell

Document Type : Review Article

Authors
Mahyar Haki 1
Mohammad Darvishi 2
1  Biomedical Engineering Department, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran.
2 School of Aerospace and Subaquatic Medicine, Infectious Diseases Research Center, Beasat Hospital, AJA University of Medical Sciences, Tehran, Iran.
10.22088/IJMCM.BUMS.14.2.777
Abstract
Colorectal cancer (CRC) is a popular type of cancer, characterized by high
mortality and a notable impression on the well-being of individuals. The success
of adoptive chimeric antigen receptor T (CAR-T) cell therapy in treating
hematological malignancies has been remarkable in recent years; however, its
application in solid tumors like CRC has many challenges. These obstacles
encompass the immunosuppressive microenvironment of the tumor, the
insufficient targeting of CAR-T cells, the limited lifespan of CAR-T cells within
the body, and the constrained capacity for proliferation. Additionally, CAR-T cells
face hurdles in effectively infiltrating the tumor site, which further complicates
treatment outcomes. Diverse innovative strategies have been suggested to
surmount these barriers in the context of CRC. This comprehensive review
endeavors to meticulously elucidate an exhaustive and detailed evaluation of the
prevailing and contemporary landscape concerning CAR-T cell therapy as it
pertains to the intricate management of CRC, while simultaneously offering a
thorough indication of the various risk factors and the associated prevalence that
are intricately linked with the manifestation and progression of CRC.
Keywords: Colorectal cancer, CAR-T cell, Treatment approaches
Keywords
Colorectal cancer
CAR-T cell
Treatment approaches