Enhancing Osteogenesis in Dental Implants: ZNF710-AS1 and miR-146a-5pin Smad Signaling Pathway Activation

Document Type : Review Article

Authors
Reza Mahmoudi Anzabi 1
Naghmeh Shenasa 2
Ali Jafarian 3
Amir Hossein Davodpour 4
Mehran Zareanshahraki 5
Mohammad Ghasemirad 6
Sajjad Rostamzadeh 7
1 Department of Orthodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
2 Endodontics Department, Shahrekord University of Medical Science, Private Practice, Shahrekord, Iran.
3 Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
4  Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
5 UCLA School of Dentistry preceptorship surgical implant dentistry, Los Angeles, California, United States of America.
6 Department of Periodontics, Faculty of Dentistry, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
7 Department of Orthodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
10.22088/IJMCM.BUMS.14.3.964
Abstract
Investigations have shown that understanding the regulatory mechanisms of the
osteogenic differentiation of periodontal ligament stem cells (PDLSCs) can significantly
enhance the regenerative capacity of periodontal tissues and mitigate periodontal
disorders. Improving osteogenesis in dental implants is complex, requiring better bone
regeneration and integration with the implant surface. ZNF710-AS1 is identified as a key
regulator of osteogenic differentiation via the BMP6/Smad pathway, with the
overexpression of miR-146a-5p and miR-146b-5p inhibiting ZNF710-AS1's osteogenic
effects. This study explores the role of the long noncoding RNA ZNF710-AS1 in PDLSC
osteogenic differentiation and clarifies its molecular mechanisms. Results indicate that
ZNF710-AS1 expression positively influences osteogenic differentiation, while miR-
146a-5p has a suppressive effect. ZNF710-AS1 serves as a competing endogenous RNA
(ceRNA) for miR-146a-5p, increasing BMP6 levels and activating the Smad signaling
pathway. The study also highlights the role of miR-146a-5p in osteogenesis and
inflammation in peri-implant tissues. Findings suggest miR-146a-5p promotes
osteogenic differentiation and could be a potential biomarker for periodontal conditions.
In summary, this research provided key insights into the molecular mechanisms of
osteogenesis and advocates for targeting ZNF710-AS1 and miR-146a-5p to improve
dental implant integration and regenerative strategies for periodontal tissues.
Keywords: Osteogenic differentiation, ZNF710-AS1, miR-146a-5p, Regulation
Keywords
Osteogenic differentiation
ZNF710-AS1
miR-146a-5p
Regulation