Trace Amine-associated Receptor 1: Role in the Implementation ofNeuroprotective Signaling Pathways

Document Type : Review Article

Authors
Mikhail Voevoda 1
Dmitry Filimonov 2
Roman Knyazev 1
Roman Ishchenko 3
Alexander Eresko 4
Nadezhda Trubnikova 5
Margarita Belotserkovskaya 5
Irina Kisilenko 6
Inna Nosova 2
Maksim Solopov 5
1 Federal State Budgetary Scientific Institution and quot, Federal Research Center for Fundamental and Translational Medicine and quot, Novosibirsk, Russia.
2  Federal State Budgetary Institution “V.K. Gusak Institute of emergency and reconstructive surgery” of the Ministry of health of the Russian .
3  Federal State Budgetary Institution “V.K. Gusak Institute of emergency and reconstructive surgery” of the Ministry of health of the Russian.
4  Frank Laboratory of Neutron Physics, Joint Institute for Nuclear Research, Dubna, Russia
5 Federal State Budgetary Institution “V.K. Gusak Institute of emergency and reconstructive surgery” of the Ministry of health of the Russian .
6  Federal State Budgetary Institution “V.K. Gusak Institute of emergency and reconstructive surgery” of the Ministry of health of the Russian
10.22088/IJMCM.BUMS.14.4.980
Abstract
Trace amine-associated receptor 1 (TAAR1) is a classical representative of G-protein
coupled receptors (GPCRs). It is widely distributed in the mammalian brain, potentially
plays an important role in modulating neurotransmitter functions and may regulate synaptic
transmission and neuronal activity. Studies on TAAR1 signaling pathways were reviewed
to identify the potential of TAAR1 as a novel target for neuroprotection and neurorepair.
TAAR1 realizes effects through binding to the G-protein subunits Gas or Ga13. The target
of Gas is PKA and the target of Ga13 is RhoA. Among the RhoA-mediated effects of
TAAR1, effects on MAPK/ERK pathway kinases, AMPA and NMDA glutamate receptors
and CREB factor have been investigated. RhoA-mediated effects include effects on the
internalization of DAT and EAAT3, neuronal transporters of dopamine and glutamate. A
G-protein independent pathway is mediated by β-arrestin and is probably related to the
formation of the TAAR1-D2R heterodimer. The modulatory effect of TAAR1 on
neurotransmitter systems allows us to consider TAAR1 agonists as potential therapeutic
agents for the treatment of neurodegenerative diseases and psychiatric disorders, as well as
neuroprotectors in ischemic brain damage.
Keywords: Trace amine-associated receptors, Signal transduction, Neuroprotection,
Neurotransmitter agents, Cyclic AMP-dependent protein kinases
Keywords
Trace amine-associated receptors
Signal transduction
Neuroprotection
Neurotransmitter agents
Cyclic AMP-dependent protein kinases