The Cross Talk of MicroRNAs and SATB2 Signaling Pathway in Osteogenesisin the Context of Dental Implants

Document Type : Review Article

Authors
Saad Alsaif
Mousa Alrashidy
Saeed Al Dossary
Restorative Department, Prince Abdulrahman Advanced Dental Institute, Riyadh, Saudi Arabia.
10.22088/IJMCM.BUMS.14.4.1099
Abstract
Dental implant integration is dependent on osteogenesis driven by the transcription factor
SATB2, which regulates osteogenic genes. MicroRNAs (miRNAs) modulate SATB2 and
influence bone formation. This review evaluates miRNA-SATB2 interactions, non-coding
RNAs, and biomaterials in dental implant osseointegration.
A critical review of studies from 2015 to 2025 was conducted to elucidate miRNA-SATB2
interactions and their impact on osteogenesis.
Inhibitory miRNAs (e.g., miR-31, miR-140-5p) suppress SATB2 via the Wnt/β-catenin
or SIRT1/Smad3 pathways and reduce osteoblast differentiation. Promoter miRNAs (e.g.,
miR-17-5p, miR-27a-5p) enhance SATB2 through BMP/Smad signaling. Non-coding
RNAs (e.g., lncRNA H19, hsa_circ_0007292) inhibit miRNAs affecting cancellous bone
and promote osteogenesis. Biomaterials such as collagen/nanohydroxyapatite (Col/nHA)
scaffolds and comorbidities (e.g., osteoporosis) influence outcomes. Inconsistent miRNA
roles and limited in vivo data are key gaps.
miRNA- SATB2 interactions are critical for implant success. Patient-specific miRNA
profiling and targeted therapies hold promise, pending clinical validation.
Keywords
Non-Coding RNA
MicroRNA
SATB2
Osteogenesis
Dental Implants
Bone Fusion
Wnt Signaling
Biomaterials